Chapter

Neuropilin: From Nervous System to Vascular and Tumor Biology

Volume 515 of the series Advances in Experimental Medicine and Biology pp 81-90

The Interaction of Neuropilin-1 and Neuropilin-2 with Tyrosine-Kinase Receptors for VEGF

  • Gera NeufeldAffiliated withDepartment of Biology, Technion, Israel Institute of Technology
  • , Ofra Kessler
  • , Yael HerzogAffiliated withDepartment of Biology, Technion, Israel Institute of Technology

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Abstract

The Neuropilin-1 (NRP 1) and Neuropilin-2 (NRP2) receptors were initially described as receptors for axon guidance factors belonging to the class-3 Semaphorin sub-family. Subsequently, it was found the Neuropilins also function as receptors for some forms of vascular endothelial growth factor (VEGF). VEGF165 binds to both NRP 1 and to NRP2 but VEGF121 does not bind to either of these receptors. VEGF145 on the other hand, binds to NRP2 but not to NRP1. Additional VEGF family members such as the heparin binding form of placenta growth factor (PIGF2) and VEGF-B bind to NRP 1, and it was also shown that both PIGF-2 and VEGFC bind to NRP2.