Abstract
A type of classical Hodgkin lymphoma composed of Reed–Sternberg and Hodgkin (RS + H) cells admixed with a uniform population of small lymphocytes. There are two variants, nodular and diffuse, and the nodular variant is most common.
In the past decade, cases of classical HL were recognized that histologically resemble NLPHL, in either a nodular or diffuse pattern, but immunophenotypically resemble the classical types of HL. In the WHO classification, these neoplasms are designated as lymphocyte-rich classical HL. Others have questioned whether lymphocyte-rich classical (LRC) HL should be designated as a distinct type, or is more simply an early or transitional form of either nodular sclerosis of mixed cellularity HL.
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Miranda, R.N., Khoury, J.D., Medeiros, L.J. (2013). Lymphocyte-Rich Classical Hodgkin Lymphoma. In: Atlas of Lymph Node Pathology. Atlas of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7959-8_72
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DOI: https://doi.org/10.1007/978-1-4614-7959-8_72
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