Impact of Genetic Targets on Therapy in Head and Neck Squamous Cell Carcinoma
- Irina ChaikhoutdinovAffiliated withDivision Otolaryngology - Head & Neck Surgery, Department Surgery, The Pennsylvania State University, The Milton S. Hershey Medical Center Email author
- , David GoldenbergAffiliated withDivision Otolaryngology - Head & Neck Surgery, Department Surgery, The Pennsylvania State University, The Milton S. Hershey Medical Center
Despite advances in surgical technique, radiation therapy and chemotherapy, the mortality from head and neck squamous cell carcinoma (HNSCC) has not improved significantly. Squamous cell carcinoma is caused by tobacco use, alcohol consumption and infection with high-risk types of human papillomavirus. It is the 6th most common cancer in the world, with upwards of 45,000 new cases reported yearly in the United States alone.
In recent years, there has been a significant increase in the understanding of the molecular and genetic pathogenesis of head and neck cancer, shedding light on the unexpected heterogeneity of the disease. Genetic analysis has led to new classification schemes for HNSCC, with different subgroups exhibiting different prognoses. In addition, multiple targets in aberrant signaling pathways have been identified using increasingly sophisticated bio-informatics tools. Advances in technology have allowed for novel delivery mechanisms to introduce genetic material into cells to produce a therapeutic effect by targeting cancer cells via a number of different approaches.
A pressing need to develop novel therapies to augment current treatment modalities has led to a number of translational studies involving gene therapy in the treatment of HNSCC. This article will focus on a review of the most recent developments in molecular biology of head and neck squamous cell carcinoma in regards to possible targets for gene therapy, as well as the array of novel therapeutic strategies directed at these targets.
KeywordsGene therapy Head and neck squamous cell carcinoma (HNSCC) Genetic targets HPV P53
- Impact of Genetic Targets on Therapy in Head and Neck Squamous Cell Carcinoma
- Book Title
- Impact of Genetic Targets on Cancer Therapy
- pp 165-177
- Print ISBN
- Online ISBN
- Series Title
- Advances in Experimental Medicine and Biology
- Series Volume
- Series ISSN
- Springer New York
- Copyright Holder
- Springer Science+Business Media New York
- Additional Links
- Gene therapy
- Head and neck squamous cell carcinoma (HNSCC)
- Genetic targets
- Industry Sectors
- Wafik S El-Deiry (ID1)
- Editor Affiliations
- Author Affiliations
- 00071. Division Otolaryngology - Head & Neck Surgery, Department Surgery, The Pennsylvania State University, The Milton S. Hershey Medical Center, 500 University Drive, 850, 17033, Hershey, PA, USA
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