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Male Infertility pp 449–458Cite as

Antioxidants in IMSI

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Abstract

Sperm morphology as assessed according to strict criteria demonstrated to have an influence on rates of fertilization, pregnancy, implantation, embryo quality and blastocyst formation. ICSI visual assessment of sperm morphology, limited by its low magnification (200x-400x) and concomitant low resolution, overlooks minor morphologic defects potentially related to sperm functional impairment. With the development of a new method for a real-time, detailed morphological evaluation of motile spermatozoa under high magnification (6600x), called MSOME, the sperm’s nucleus turned out to be the most important parameter influencing ICSI outcome particularly in the form of large nuclear vacuoles that were proposed to reflect damages in the nuclear DNA content and organization.

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Acknowledgment

The author gratefully acknowledge the help of Mrs Stella Antinori in the preparation of the manuscript.

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  1. Department of Infertility, RAPRUI Day Surgery, Via Timavo 2, 00193, Rome, Italy

    Monica Antinori MD

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  1. Monica Antinori MD
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  1. University of Florida, Director, Robotic Surgery, Winter Haven Hospital &, 200 Avenue F. N.E., Winter Haven, 33881, Florida, USA

    Sijo J. Parekattil

  2. Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Euclid Avenue 9500, Cleveland, 44195, Ohio, USA

    Ashok Agarwal

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Antinori, M. (2012). Antioxidants in IMSI. In: Parekattil, S., Agarwal, A. (eds) Male Infertility. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3335-4_43

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