Volume 746 of the series Advances in Experimental Medicine and Biology pp 95-108

Immunotherapeutic Approach with Oligodeoxynucleotides Containing CpG Motifs (CpG-ODN) in Malignant Glioma

  • Renata UrsuAffiliated withService de Neurologie, Hôpital Avicenne
  • , Antoine F. CarpentierAffiliated withService de Neurologie, Hôpital Avicenne Email author 

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Bacterial DNA and synthetic oligodeoxynucleotides containing CpG motifs (CpG-ODNs) are strong activators of both innate and specific immunity, driving the immune response towards the Th1 phenotype. In cancer patients, CpG-ODNs can be used to activate the innate immunity and trigger a tumor-specific immune response. Several clinical trials are on-going worldwide in various cancers. In this chapter, we will focus on the potential applications of CpG-ODNs in glioma. So far, CpG-ODN has mainly been used by intratumoral injections. Indeed, human gliomas display a locally invasive pattern of growth and rarely metastasize, making local treatment clinically relevant.