Chapter

Multifunctional Nanoparticles for Drug Delivery Applications

Part of the series Nanostructure Science and Technology pp 9-29

Date:

Nanoparticles for Targeted and Temporally Controlled Drug Delivery

  • Archana SwamiAffiliated withDepartment of Anesthesiology, Laboratory of Nanomedicine and Biomaterials, Brigham and Women’s Hospital, and Harvard Medical School
  • , Jinjun ShiAffiliated withDepartment of Anesthesiology, Laboratory of Nanomedicine and Biomaterials, Brigham and Women’s Hospital, and Harvard Medical School
  • , Suresh GaddeAffiliated withDepartment of Anesthesiology, Laboratory of Nanomedicine and Biomaterials, Brigham and Women’s Hospital, and Harvard Medical School
  • , Alexander R. VotrubaAffiliated withDepartment of Anesthesiology, Laboratory of Nanomedicine and Biomaterials, Brigham and Women’s Hospital, and Harvard Medical School
  • , Nagesh KolishettiAffiliated withDepartment of Anesthesiology, Laboratory of Nanomedicine and Biomaterials, Brigham and Women’s Hospital, and Harvard Medical School
  • , Omid C. FarokhzadAffiliated withDepartment of Anesthesiology, Laboratory of Nanomedicine and Biomaterials, Brigham and Women’s Hospital, and Harvard Medical School Email author 

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Abstract

With advances in nanotechnology, it is now possible to develop highly specific and effective treatments for a myriad of important human diseases including cancer and cardiovascular and inflammatory diseases. One important obstacle in the development of safer and more effective therapeutics has been the challenge of delivering drugs to the site of action at an optimal exposure and rate. The design and development of biocompatible, targeted nanoparticles that control the release of drugs at the site of interest has the potential to revolutionize drug development and enable entirely new therapeutic approaches such as RNA interference (RNAi). This chapter gives an insight into the development of nanoparticle platforms for the targeted and temporally controlled delivery of drugs with minimal off target effects and reviews the available classes of ligands for targeting applications.