Chapter

Notch Signaling in Embryology and Cancer

Volume 727 of the series Advances in Experimental Medicine and Biology pp 114-130

Notch Signaling and the Developing Skeleton

  • Timothy J. MeadAffiliated withDivision of Molecular Cardiovascular Biology, Cincinnati Children’s Hospital Medical Center
  • , Katherine E. YutzeyAffiliated withDivision of Molecular Cardiovascular Biology, Cincinnati Children’s Hospital Medical Center Email author 

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Abstract

Notch signaling is an important regulator of skeletogenesis at multiple developmental stages. The Notch signaling pathway is involved in the promotion of somite segmentation, patterning and differentiation into sclerotome pre-chondrogenic cells to allow for appropriate axial skeleton development. In addition, studies performed in vitro and in vivo demonstrate that Notch signaling suppresses chondrogenic and osteoblastic differentiation and negatively regulates osteoclast formation and proliferation. Through the use of in vitro and in vivo approaches, Notch signaling has been shown to regulate somitogenesis, chondrogenesis, osteoblastogenesis and osteoclastogenesis that ultimately affect skeletogenesis. Dysregulation of Notch signaling results in congenital skeletal malformations that could reveal therapeutic potential.