Chapter

Current Topics in Innate Immunity II

Volume 946 of the series Advances in Experimental Medicine and Biology pp 113-133

Date:

Advances in Understanding the Structure, Function, and Mechanism of the SCIN and Efb Families of Staphylococcal Immune Evasion Proteins

  • Brandon L. GarciaAffiliated withSchool of Biological Sciences, University of Missouri
  • , Kasra X. RamyarAffiliated withSchool of Biological Sciences, University of Missouri
  • , Daniel RicklinAffiliated withSchool of Medicine, University of Pennsylvania
  • , John D. LambrisAffiliated withSchool of Medicine, University of Pennsylvania
  • , Brian V. GeisbrechtAffiliated withSchool of Biological Sciences, University of Missouri Email author 

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Abstract

Our understanding of both the nature and diversity of Staphylococcal immune evasion proteins has increased tremendously throughout the last several years. Among this group of molecules, members of the SCIN and Efb families of complement inhibitors have been the subject of particularly intense study. This work has demonstrated that both types of proteins exert their primary function by inhibiting C3 convertases, which lie at the heart of the complement-mediated immune response. Despite this similarity, however, significant differences in structure/function relationships and mechanisms of action exist between these bacterial proteins. Furthermore, divergent secondary effects on host immune responses have also been described for these two protein families. This chapter summarizes recent advances toward understanding the structure, function, and mechanism of the SCIN and Efb families, and suggests potential directions for the field over the coming years.

Keywords

Immune Evasion Complement Inhibitors Staphylococcus aureus Structural Biology Mechanism C3 Convertase SCIN Efb