Current Topics in Innate Immunity II

Volume 946 of the series Advances in Experimental Medicine and Biology pp 1-20


Pentraxins in Humoral Innate Immunity

  • Antonio InforzatoAffiliated withIstituto Clinico Humanitas IRCCS
  • , Barbara BottazziAffiliated withIstituto Clinico Humanitas IRCCS
  • , Cecilia GarlandaAffiliated withIstituto Clinico Humanitas IRCCS
  • , Sonia ValentinoAffiliated withIstituto Clinico Humanitas IRCCS
  • , Alberto MantovaniAffiliated withIstituto Clinico Humanitas IRCCSDepartment of Translational Medicine, University of Milan Email author 

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Innate immunity represents the first line of defence against pathogens and plays key roles in activation and orientation of the adaptive immune response. The innate immune system comprises both a cellular and a humoral arm. Components of the humoral arm include soluble pattern recognition molecules (PRMs) that recognise pathogens associated molecular patterns (PAMPs) and initiate the immune response in coordination with the cellular arm, therefore acting as functional ancestors of antibodies. The long pentraxin PTX3 is a prototypic soluble PRM that is produced at sites of infection and inflammation by both somatic and immune cells. Gene targeting of this evolutionarily conserved protein has revealed a non-redundant role in resistance to selected pathogens. Moreover, PTX3 exerts important functions at the crossroad between innate immunity, inflammation and female fertility. Here we review the studies on PTX3, with emphasis on pathogen recognition and crosstalk with other components of the innate immune system.


Pentraxins PTX3 Inflammation Innate immunity Tissue remodeling Biomarkers