Chapter

Brain Acetylcholine and Neuropsychiatric Disease

pp 155-172

Alterations in Muscarinic Cholinergic Receptor Binding in Huntington’s Disease

  • H. I. YamamuraAffiliated withDepartment of Pharmacology, College of Medicine, The University of Arizona Health Sciences Center
  • , G. J. WastekAffiliated withDepartment of Pharmacology, College of Medicine, The University of Arizona Health Sciences Center
  • , R. E. HruskaAffiliated withDepartment of Pharmacology, College of Medicine, The University of Arizona Health Sciences Center

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Abstract

Dramatic advances have been made in recent years in the identification and isolations of hormonal receptors (Sica et al., 1976) and of the nicotinic cholinergic receptors of invertebrates (Changeux, 1975). Patrick and Lindstrom (1973) have administered a solubilized and purified form of the nicotinic cholinergic receptor from the electric organ of the eel or fish into animals and have produced a flaccid paralysis which electromyographically and pharmacologically exhibits similar symptoms to myasthenia gravis. Tremendous gains have been made towards understanding the autoimmune aspects of this debilitating disease (Elias and Appel, 1976, Lindstrom et al., 1976).