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Neural Membranes pp 459–477Cite as

Gangliosides of the Neuronal Membrane and the Neuritogenic Phenomenon

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Part of the book series: Experimental and Clinical Neuroscience ((ECN))

Abstract

Gangliosides, since their discovery over four decades ago, have been proposed to subserve a variety of functions commensurate with their broad distribution among vertebrate cells and their remarkable structural diversity (Macher and Sweeley, 1978: Brunngraber, 1979: Svennerholm et al, 1980: Rapport and Gorio, 198l: Hakomori, 1981: Ledeen and Yu, 1982: Wiegandt, 1982: Makita et al, 1982: Ledeen, 1983). Although it is no longer possible to view these substances as neuronal markers, special interest still attaches to their putative role(s) in neurons owing to their unusually high concentration in the central nervous system. Thus, their concentration in gray matter exceeds that in liver by approximately 14-fold (Svennerholm et al, 1972; Seyfried et al, 1978; Ledeen and Yu, 1982). At the same time it is recognized that great diversity exists among neurons, those of theperipheral nervous system, for example, possessing considerably lower concentrations than those of brain. Molecular patterns are also found to vary among different neuronal types.

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Authors and Affiliations

  1. The Departments of Neurology and Biochemistry, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Robert W. Ledeen, Mary C. Byrne, Fred J. Roisen Glee Yorke & Joseph R. Sclafani

  2. The Department of Anatomy, UMDNJ-Rutgers Medical School, Piscataway, NJ, O8854, USA

    Robert W. Ledeen, Mary C. Byrne, Fred J. Roisen Glee Yorke & Joseph R. Sclafani

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  1. Robert W. Ledeen
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  2. Mary C. Byrne
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  3. Fred J. Roisen Glee Yorke
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  4. Joseph R. Sclafani
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Grace Y. Sun Nicolas Bazan Jang-Yen Wu Guiseppe Porcellati Albert Y. Sun

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Ledeen, R.W., Byrne, M.C., Roisen Glee Yorke, F.J., Sclafani, J.R. (1983). Gangliosides of the Neuronal Membrane and the Neuritogenic Phenomenon. In: Sun, G.Y., Bazan, N., Wu, JY., Porcellati, G., Sun, A.Y. (eds) Neural Membranes. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-5636-6_23

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