Pathobiology of the Human Atherosclerotic Plaque

pp 93-106

Changes in the Cells of Atherosclerotic Lesions as Advanced Lesions Evolve in Coronary Arteries of Children and Young Adults

  • H. C. Stary

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As early as 1913 Anitschkow (1) described the cells of the aortic intimal lesions of rabbits that had been eating food rich in cholesterol. In his drawings of lesions, Anitschkow pictured both smooth muscle cells and macrophages. Some of the macrophage foam cells are pictured in mitosis, and lesion smooth muscle cells are described as modified (equivalent to the terms RER-rich or synthetic). His observations, although limited by the methods of his time, remain nevertheless valid not only for experimental atherosclerotic lesions, but also for human lesions.