Abstract
In 1964 it was observed that small microscopic particles could be absorbed from the intestinal canal into the mesenteric circulation and into the lymphatics of the gastrointestinal tract.1 This phenomenon was termed “persorption.” Shortly after these observations, a technique was developed for the quantitative measurement of endotoxin in human plasma using the lysate technique of the horseshoe crab Limulus.2 It was next demonstrated that tissue homogenates obtained postmortem had measurable levels of endotoxin in 20 of 35 patients, particularly following major trauma, gastrointestinal (GI) bleeding, and liver injury. The findings were explained on the basis of failure of the reticuloendothelial system of the liver to detoxify circulating endotoxin of intestinal origin.
Keywords
- Hemorrhagic Shock
- Intestinal Permeability
- Horseshoe Crab
- Endotoxin Level
- Selective Digestive Decontamination
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Munster, A.M. (2000). Gut: Clinical Importance of Bacterial Translocation, Permeability, and Other Factors. In: Baue, A.E., Faist, E., Fry, D.E. (eds) Multiple Organ Failure. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1222-5_9
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DOI: https://doi.org/10.1007/978-1-4612-1222-5_9
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