Abstract
Several types of nanotechnology-enabled plastics intended for the storage and transport of foods are close to commercialization. For food contact applications, nanocomposite plastics offer many advantages over traditional polymers. However, while the unique properties of engineered nanomaterials (ENMs) may be harnessed for many positive ends, there are concerns about whether ENMs pose risks to human health. The primary areas of interest for assessing safety of nanocomposite food contact materials (FCM) are the potential for migration of ENMs into food and the potential toxicity of such released ENMs. This chapter offers a review of theoretical and experimental methods to assess the likelihood of ENM release from nanotechnology-enabled materials into liquid media, as well as a brief overview of the potential toxicological considerations of ENMs likely to be used in FCMs. Because the use of nanotechnology in food contact applications is a developing field, this chapter also provides background information on some of the food-related applications of nanocomposites currently in development, and a discussion of current methods being used to assess the release of non-nanoscale food packaging additives or contaminants. The goal of this work is to provide readers with an appreciation for current activity in this field as well as an understanding of data gaps that may need to be addressed in order to ensure the safety of this emerging technology.
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There are additional exemptions (e.g., pesticides and color additives), which have their own separate regulatory definitions.
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Migration ratio was defined as the ratio of amount of silver in the food simulant at the end of the migration experiment to the amount of silver in the film prior to the migration experiment.
References
Alger H, Momcilovic D, Carlander D et al (2014) Methods to evaluate uptake of engineered nanomaterials by the alimentary tract. Compr Rev Food Sci Food Saf. doi:10.1111/1541-4337.12077
Albanese A, Tang PS, Chan WCW (2012) The effect of nanoparticle size, shape, and surface chemistry on biological systems. Annu Rev Biomed Eng 14:1–16
Alissawi N, Zaporojtchenko V, Strunskus T et al (2012) Tuning of the ion release properties of silver nanoparticles buried under a hydrophobic polymer barrier. J Nanopart Res 14(7):1–12
Asare N, Instanes C, Sandberg WJ et al (2012) Cytotoxic and genotoxic effects of silver nanoparticles in testicular cells. Toxicology 291(1–3):65–72
Avella M, De Vlieger JJ, Errico ME et al (2005) Biodegradable starch/clay nanocomposite films for food packaging applications. Food Chem 93(3):467–474
Avella M, Bruno G, Errico ME et al (2007) Innovative packaging for minimally processed fruits. Packag Technol Sci 20(5):325–335
Balasubramanyam A, Sailaja N, Mahboob M et al (2009) Evaluation of genotoxic effects of oral exposure to aluminum oxide nanomaterials in rat bone marrow. Mutat Res 676(1–2):41–47
Begley TH, Gay ML, Hollifield HC (1995) Determination of migrants in and migration from nylon food-packaging. Food Addit Contam 12(5):671–676
Begley T, Castle L, Feigenbaum A et al (2005) Evaluation of migration models that might be used in support of regulations for food-contact plastics. Food Addit Contam 22(1):73–90
Bouwmeester H, Dekkers S, Noordam MY et al (2009) Review of health safety aspects of nanotechnologies in food production. Regul Toxicol Pharmacol 53(1):52–62
Brandsch J, Mercea P, Ruter M et al (2002) Migration modelling as a tool for quality assurance of food packaging. Food Addit Contam 19:29–41
Busolo MA, Fernandez P, Ocio MJ et al (2010) Novel silver-based nanoclay as an antimicrobial in polylactic acid food packaging coatings. Food Addit Contam 27A(11):1617–1626
Card JW, Magnuson BA (2010) A method to assess the quality of studies that examine the toxicity of engineered nanomaterials. Int J Toxicol 29(4):402–410
Card JW, Jonaitis TS, Tafazoli S et al (2011) An appraisal of the published literature on the safety and toxicity of food-related nanomaterials. Crit Rev Toxicol 41(1):20–49
Cerrada ML, Serrano C, Sánchez-Chaves M et al (2008) Self-sterilized EVOH-TiO2 nanocomposites: interface effects on biocidal properties. Adv Funct Mater 18(13):1949–1960
Chawengkijwanich C, Hayata Y (2008) Development of TiO2 powder-coated food packaging film and its ability to inactivate Escherichia coli in vitro and in actual tests. Int J Food Microbiol 123(3):288–292
Cho W-S, Kang B-C, Lee JK et al (2013) Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration. Part Fibre Toxicol 10:9
Choudalakis G, Gotsis AD (2009) Permeability of polymer/clay nanocomposites: a review. Eur Polym J 45(4):967–984
Code of Federal Regulations (CRC) (2013) 21CFC170.3, Title 21, Vol. 3, Part 170, Food Additives; Section 170.3(i) Definitions; definition of safety. http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=170.3. Accessed 20 Oct 2013
Cushen M, Kerry J, Morris M et al (2013) Migration and exposure assessment of silver from a PVC nanocomposite. Food Chem 139(1–4):389–397
de Azeredo HMC (2013) Antimicrobial nanostructures in food packaging. Trends Food Sci Technol 30(1):56–69
de Moura MR, Lorevice MV, Mattoso LHC et al (2011) Highly stable, edible cellulose films incorporating chitosan nanoparticles. J Food Sci 76(2):S25–S29
Dhar S, Mali V, Bodhankar S et al (2011) Biocompatible gellan gum-reduced gold nanoparticles: cellular uptake and subacute oral toxicity studies. J Appl Toxicol 31(5):411–420
Diaz CA, Xia Y, Rubino M et al (2013) Fluorescent labeling and tracking of nanoclay. Nanoscale 5(1):164–168
Duan Y, Liu J, Ma L et al (2010) Toxicological characteristics of nanoparticulate anatase titanium dioxide in mice. Biomaterials 31(5):894–899
Duncan TV (2011a) Applications of nanotechnology in food packaging and food safety: barrier materials, antimicrobials and sensors. J Colloid Interface Sci 363(1):1–24
Duncan TV (2011b) The communication challenges presented by nanofoods. Nat Nanotechnol 6(11):683–688
Emamifar A, Kadivar M, Shahedi M et al (2011) Effect of nanocomposite packaging containing Ag and ZnO on inactivation of Lactobacillus plantarum in orange juice. Food Control 22(3–4):408–413
Eom HJ, Choi J (2010) p38 MAPK activation, DNA damage, cell cycle arrest and apoptosis as mechanisms of toxicity of silver nanoparticles in Jurkat T cells. Environ Sci Technol 44(21):8337–8342
European Food Safety Authority (EFSA) Scientific Committee (2009) The potential risks arising from nanoscience and nanotechnologies on food and feed safety. EFSA J 958:1–39. doi:10.2903/j.efsa.2009.958, http://www.efsa.europa.eu/en/efsajournal/pub/958.htm. Accessed 24 Oct 2013
European Food Safety Authority (EFSA) Scientific Committee (2011) Guidance on the risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain. EFSA J 9(5):2140. doi:10.2903/j.efsa.2011.2140, http://www.efsa.europa.eu/en/efsajournal/pub/2140.htm. Accessed 24 Oct 2013
Fang XY, Domenek S, Ducruet V et al (2013) Diffusion of aromatic solutes in aliphatic polymers above glass transition temperature. Macromolecules 46(3):874–888
Farhoodi M, Mousavi SM, Sotudeh-Gharebagh R et al (2013) Migration of aluminum and silicon from PET/clay nanocomposite bottles into acidic food simulant. Packag Technol Sci. doi:10.1002/pts.2017
Fayaz AM, Balaji K, Girilal M et al (2009) Mycobased synthesis of silver nanoparticles and their incorporation into sodium alginate films for vegetable and fruit preservation. J Agric Food Chem 57(14):6246–6252
Fernández A, Picouet P, Lloret E (2010) Reduction of the spoilage-related microflora in absorbent pads by silver nanotechnology during modified atmosphere packaging of beef meat. J Food Prot 73(12):2263–2269
Food and Drug Administration (FDA) (2007) Guidance for industry: preparation of premarket submissions for food contact substances: chemistry recommendations. http://www.fda.gov/Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformation/IngredientsAdditivesGRASPackaging/ucm081818.htm. Accessed 20 Oct 2013
Food and Drug Administration (FDA) (2011) Considering whether an FDA-regulated product involves the application of nanotechnology. http://www.fda.gov/regulatoryinformation/guidances/ucm257698.htm. Accessed 20 Oct 2013
Fortunati E, Latterini L, Rinaldi S et al (2011) PLGA/Ag nanocomposites: in vitro degradation study and silver ion release. J Mater Sci Mater Med 22(12):2735–2744
Fröhlich E, Roblegg E (2012) Models for oral uptake of nanoparticles in consumer products. Toxicology 291(1–3):10–17
Gaiser BK, Fernandes TF, Jepson MA et al (2012) Interspecies comparisons on the uptake and toxicity of silver and cerium dioxide nanoparticles. Environ Toxicol Chem 31(1):144–154
Hackenberg S, Scherzed A, Technau A et al (2011) Cytotoxic, genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitro. Toxicol In Vitro 25(3):657–663
Hadrup N, Loeschner K, Bergström A et al (2012) Subacute oral toxicity investigation of nanoparticulate and ionic silver in rats. Arch Toxicol 86(4):543–551
Hahn A, Brandes G, Wagener P et al (2011) Metal ion release kinetics from nanoparticle silicone composites. J Control Release 154(2):164–170
Huang YM, Chen S, Bing X et al (2011) Nanosilver migrated into food-simulating solutions from commercially available food fresh containers. Packag Technol Sci 24(5):291–297
Jia X, Li N, Chen J (2005) A subchronic toxicity study of elemental Nano-Se in Sprague-Dawley rats. Life Sci 76(17):1989–2003
Kim YS, Kim JS, Cho HS et al (2008) Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats. Inhalation Toxicol 20(6):575–583
Kim S, Choi JE, Choi J et al (2009) Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells. Toxicol In Vitro 23(6):1076–1084
Kim YS, Song MY, Park JD et al (2010) Subchronic oral toxicity of silver nanoparticles. Part Fibre Toxicol 7:20
Kim JS, Song SS, Sung JH et al (2013) Genotoxicity, acute oral and dermal toxicity, eye and dermal irritation and corrosion and skin sensitisation evaluation of silver nanoparticles. Nanotoxicology 7(5):953–960
Kittler S, Greulich C, Diendorf J et al (2010) Toxicity of silver nanoparticles increases during storage because of slow dissolution under release of silver ions. Chem Mater 22(16):4548–4554
Li H, Li F, Wang L et al (2009) Effect of nano-packing on preservation quality of Chinese jujube (Ziziphus jujuba Mill. var. inermis (Bunge) Rehd). Food Chem 114(2):547–552
Lin J-J, Lin W-C, Dong R-X et al (2012) The cellular responses and antibacterial activities of silver nanoparticles stabilized by different polymers. Nanotechnology 23(6):065102
Liu W, Wu Y, Wang C et al (2010) Impact of silver nanoparticles on human cells: effect of particle size. Nanotoxicology 4(3):319–330
Loeschner K, Hadrup N, Qvortrup K et al (2011) Distribution of silver in rats following 28 days of repeated oral exposure to silver nanoparticles or silver acetate. Part Fibre Toxicol 8:18
Longano D, Ditaranto N, Cioffi N et al (2012) Analytical characterization of laser-generated copper nanoparticles for antibacterial composite food packaging. Anal Bioanal Chem 403(4):1179–1186
Luque-Garcia JL, Sanchez-Díaz R, Lopez-Heras I et al (2013) Bioanalytical strategies for in vitro and in vivo evaluation of the toxicity induced by metallic nanoparticles. TrAC Trends Anal Chem 43:254–268
Maneewattanapinyo P, Banlunara W, Thammacharoen C et al (2011) An evaluation of acute toxicity of colloidal silver nanoparticles. J Vet Med Sci 73(11):1417–1423
Marsh K, Bugusu B (2007) Food packaging—roles, materials, and environmental issues. J Food Sci 72(3):R39–R55
Mauricio-Iglesias M, Peyron S, Guillard V et al (2010) Wheat gluten nanocomposite films as food-contact materials: migration tests and impact of a novel food stabilization technology (high pressure). J Appl Polym Sci 116(5):2526–2535
Mauricio-Iglesias M, Gontard N, Gastaldi E (2011) Impact of high pressure treatment on the structure of montmorillonite. Appl Clay Sci 51(1–2):174–176
Mollahosseini A, Rahimpour A, Jahamshahi M et al (2012) The effect of silver nanoparticle size on performance and antibacteriality of polysulfone ultrafiltration membrane. Desalination 306:41–50
Noonan GO, Whelton AJ, Carlander D et al (2014) Measurement methods to evaluate engineered nanomaterial release from food contact materials. Comp Rev Food Sci Food Saf. doi:10.1111/1541-4337.12079
Paladini F, Pollini M, Talá A et al (2012) Efficacy of silver treated catheters for haemodialysis in preventing bacterial adhesion. J Mater Sci Mater Med 23(8):1983–1990
Park EJ, Bae E, Yi J et al (2010) Repeated-dose toxicity and inflammatory responses in mice by oral administration of silver nanoparticles. Environ Toxicol Pharmacol 30(2):162–168
Park E-J, Kim H, Kim Y et al (2011a) Repeated-dose toxicity attributed to aluminum nanoparticles following 28-day oral administration, particularly on gene expression in mouse brain. Toxicol Environ Chem 93(1):120–133
Park K, Park E-J, Chun IK et al (2011b) Bioavailability and toxicokinetics of citrate-coated silver nanoparticles in rats. Arch Pharmacol Res 34(1):153–158
Piao MJ, Kang KA, Lee IK et al (2011) Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis. Toxicol Lett 201(1):92–100
Podsiadlo P, Kaushik AK, Arruda EM et al (2007) Ultrastrong and stiff layered polymer nanocomposites. Science 318(5847):80–83
Ray SS, Yamada K, Okamoto M et al (2002) Polylactide-layered silicate nanocomposite: a novel biodegradable material. Nano Lett 2(10):1093–1096
Risch SJ (2009) Food packaging history and innovations. J Agric Food Chem 57(18):8089–8092
Robertson GL (2006) Food packaging: principles and practice, 2nd edn. Taylor and Francis Group, LLC, Boca Raton
Rulis AM, Levitt JA (2009) FDA’s food ingredient approval process, safety assurance based on scientific assessment. Regul Toxicol Pharmacol 53(1):20–31
Sánchez-Valdes S, Ortega-Ortiz H, Ramos-de Valle LF et al (2009) Mechanical and antimicrobial properties of multilayer films with a polyethylene/silver nanocomposite layer. J Appl Polym Sci 111(2):953–962
Schmidt B, Petersen JH, Koch CB et al (2009) Combining asymmetrical flow field-flow fractionation with light-scattering and inductively coupled plasma mass spectrometric detection for characterization of nanoclay used in biopolymer nanocomposites. Food Addit Contam 26A(12):1619–1627
Schmidt B, Katiyar V, Plackett D et al (2011) Migration of nanosized layered double hydroxide platelets from polylactide nanocomposite films. Food Addit Contam 28A(7):956–966
Seil JT, Webster TJ (2012) Antimicrobial applications of nanotechnology: methods and literature. Int J Nanomed 7:2767–2781
Seok SH, Cho W-S, Park JS et al (2013) Rat pancreatitis produced by 13-week administration of zinc oxide nanoparticles: biopersistence of nanoparticles and possible solutions. J Appl Toxicol 33(10):1089–1096
Šimon P, Chaudhry Q, Bakoš D (2008) Migration of engineered nanoparticles from polymer packaging to food—a physicochemical view. J Food Nutr Res 47(3):105–113
Song H, Li B, Lin Q-B et al (2011) Migration of silver from nanosilver-polyethylene composite packaging into food simulants. Food Addit Contam 28(12):1758–1762
Strohal R, Schelling M, Takacs M et al (2005) Nanocrystalline silver dressings as an efficient anti-MRSA barrier: a new solution to an increasing problem. J Hosp Infect 60(3):226–230
Sweet MJ, Singleton I (2011) Silver nanoparticles: a microbial perspective. Adv Appl Microbiol 77:115–133
United States Code (2010) 21 United States Code, 2010 Edition, Title 21—Food and Drugs, Chapter 9 – Federal Food, Drug, and Cosmetic Act, Subchapter II – Definitions; Section 321, Definition for food additive. http://www.gpo.gov/fdsys/pkg/U.S.CODE-2010-title21/html/U.S.CODE-2010-title21-chap9-subchapII.htm. Accessed 20 Oct 2013
United States Environmental Protection Agency (USEPA) (2013) Municipal solid waste. U.S. Environmental Protection Agency. http://www.epa.gov/epawaste/nonhaz/municipal/. Accessed 30 June 2014
van der Zande M, Vandebriel RJ, Van Doren E et al (2012) Distribution, elimination, and toxicity of silver nanoparticles and silver ions in rats after 28-day oral exposure. ACS Nano 6(8):7427–7442
Wang Y, Chen Z, Ba T et al (2013) Susceptibility of young and adult rats to the oral toxicity of titanium dioxide nanoparticles. Small 9(9–10):1742–1752
Welle F (2013) A new method for the prediction of diffusion coefficients in poly(ethylene terephthalate). J Appl Polym Sci 129:1845–1851
Xia X, Tang Y, Xie C et al (2011) An approach to give prospective life-span of the copper/low-density-polyethylene nanocomposite intrauterine device. J Mater Sci Mater Med 22(7):1773–1781
Xiu Z-M, Zhang Q-B, Puppala HL et al (2012) Negligible particle-specific antibacterial activity of silver nanoparticles. Nano Lett 12(8):4271–4275
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Pillai, K.V., Hunt, P.R., Duncan, T.V. (2014). Nanoparticles in Polymer Nanocomposite Food Contact Materials: Uses, Potential Release, and Emerging Toxicological Concerns. In: Snedeker, S. (eds) Toxicants in Food Packaging and Household Plastics. Molecular and Integrative Toxicology. Springer, London. https://doi.org/10.1007/978-1-4471-6500-2_4
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