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Mathematical Modeling in Nutrition and the Health Sciences

Volume 537 of the series Advances in Experimental Medicine and Biology pp 21-42

Cornerstones to Shape Modeling for the 21st Century: Introducing the AKA-Glucose Project

  • Ray BostonAffiliated withBiomathematics Unit, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania
  • , Darko StefanovskiAffiliated withBiomathematics Unit, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania
  • , Peter MoateAffiliated withBiomathematics Unit, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania
  • , Oscar LinaresAffiliated withUniversity of Michigan Geriatrics Clinic
  • , Peter GreifAffiliated withLaboratory of Computational and Experimental Biology, Division of Cancer Biology and Diagnosis, National Cancer Institute

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Abstract

For some reason, the start of a new century, as though magically demarcating history, seems to confer the right to reflect on progress as we embrace a ‘new’ period or ‘new’ phase of endeavor. Accordingly, we begin this paper by reviewing what computer-based mathematical modeling in biology (CMMB) has brought us thus far, as we begin the 21st century (or could we say, ‘the third millennium’,). We will decompose the stages of CMMB evolution in the last century into three generations, noting the hallmark accomplishments in each.