Angiogenesis in Brain Tumors

Volume 117 of the series Cancer Treatment and Research pp 191-218

Role of VEGF in Developmental Angiogenesis and in Tumor Angiogenesis in the Brain

  • Marcia Regina MacheinAffiliated withDepartment of Neurosurgery, University of Freiburg
  • , Karl Heinz PlateAffiliated withEdinger-Institut, Institute of Neurology, University of Frankfurt

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For more than 100 years tumors have been observed to be more vascular than normal tissues. This tumor hyperemia was first explained as a result of simple vessel dilation of existing host blood vessels, or as inflammatory reaction in response to tumor growth.