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Frontiers in Molecular Imaging of Cartilage: Future Developments

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Book cover Cartilage Imaging

Abstract

Recent research has led to the development of drugs that, in animal models, have shown the potential of protecting against the breakdown of macromolecules in cartilage, effectively halting the progression of OA. Because of the long natural history of OA (10–20 years in humans), validating the efficacy of these drugs over the natural course of the disease is not feasible. Instead, what is needed is a validated noninvasive imaging biomarker that can directly assess their effect on molecular changes associated with early stages of cartilage degeneration that precede morphological changes.

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Authors and Affiliations

  1. Department of Radiology, School of Medicine, University of Pennsylvania, 422 Curie Blvd, B1-Stellar-Chance Laboratory, Philadelphia, PA, 19104-6100, USA

    Ravinder Reddy

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  2. Arijitt Borthakur
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Correspondence to Ravinder Reddy .

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  1. Dept. Radiology, University of California, San Francisco, 400 Parnassus Ave., A-367, San Francisco, 94143-0628, California, USA

    Thomas M. Link

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Reddy, R., Borthakur, A., Witschey, W.R.T., Kneeland, J.B. (2011). Frontiers in Molecular Imaging of Cartilage: Future Developments. In: Link, T. (eds) Cartilage Imaging. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8438-8_17

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-8437-1

  • Online ISBN: 978-1-4419-8438-8

  • eBook Packages: MedicineMedicine (R0)

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