Effects of Assuming Constant Optical Scattering on Haemoglobin Concentration Measurements Using NIRS during a Valsalva Manoeuvre

  • Lei Gao
  • Clare E. ElwellElwell
  • Matthias Kohl-Bareis
  • Marcus Gramer
  • Chris E. Cooper
  • Terence S. Leung
  • Ilias Tachtsidis
Conference paper

DOI: 10.1007/978-1-4419-7756-4_3

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 701)
Cite this paper as:
Gao L. et al. (2011) Effects of Assuming Constant Optical Scattering on Haemoglobin Concentration Measurements Using NIRS during a Valsalva Manoeuvre. In: LaManna J., Puchowicz M., Xu K., Harrison D., Bruley D. (eds) Oxygen Transport to Tissue XXXII. Advances in Experimental Medicine and Biology, vol 701. Springer, Boston, MA

Abstract

Resolving for changes in concentration of tissue chromophores in the human adult brain with near-infrared spectroscopy has generally been based on the assumption that optical scattering and pathlength remain constant. We have used a novel hybrid optical spectrometer that combines multi-distance frequency and broadband systems to investigate the changes in scattering and pathlength during a Valsalva manoeuvre in 8 adult volunteers. Results show a significant increase in the reduced scattering coefficient of 17% at 790nm and 850nm in 4 volunteers during the peak of the Valsalva. However, these scattering changes do not appear to significantly affect the differential pathlength factor and the tissue haemoglobin concentration measurements.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Lei Gao
    • 1
  • Clare E. ElwellElwell
    • 1
  • Matthias Kohl-Bareis
    • 2
  • Marcus Gramer
    • 2
  • Chris E. Cooper
    • 3
  • Terence S. Leung
    • 1
  • Ilias Tachtsidis
    • 1
  1. 1.Biomedical Optics Research Laboratory, Department ofMedical Physics and BioengineeringUniversity College LondonLondonUK
  2. 2.University of Applied Sciences KoblenzRemagenGermany
  3. 3.Department of Biological SciencesUniversity of EssexColchester EssexUK

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