Neonatal Herpes Simplex Virus Infections: Where Are We Now?
- Clara ThompsonAffiliated withPaediatrics, John Radcliffe Children’s Hospital
- , Richard WhitleyAffiliated withPaediatrics, Microbiology, Medicine and Neurosurgery, The University of Alabama Email author
Neonatal herpes simplex virus (HSV) infection continues to cause significant morbidity and mortality despite advances in diagnosis and treatment. Prior to antiviral therapy, 85% of patients with disseminated HSV disease and 50% of patients with central nervous system disease died within 1 year. The advent of antiviral therapy has dramatically improved the prognosis of neonatal HSV with initially vidarabine and subsequently acyclovir increasing the survival rate of infected neonates and improving long-term developmental outcomes. More recently, polymerase chain reaction has allowed earlier identification of HSV infection and provided a quantitative guide to treatment. Current advances in the treatment of neonatal HSV infections are looking toward the role of prolonged oral suppression therapy in reducing the incidence of recurrent disease. Of concern, however, are increasing reports of acyclovir-resistant HSV isolates in patients following prolonged therapy.
- Neonatal Herpes Simplex Virus Infections: Where Are We Now?
- Book Title
- Hot Topics in Infection and Immunity in Children VII
- pp 221-230
- Print ISBN
- Online ISBN
- Series Title
- Advances in Experimental Medicine and Biology
- Series Volume
- Series ISSN
- Springer New York
- Copyright Holder
- Springer Science+Business Media, LLC
- Additional Links
- Industry Sectors
- eBook Packages
- Editor Affiliations
- ID1. Royal Children's Hospital, Dept. Pediatrics, University of Melbourne
- ID2. Institute of Child Life and Health, UBHT Education Centre, University of Bristol
- ID3. University of Oxford
- Author Affiliations
- 1. Paediatrics, John Radcliffe Children’s Hospital, Oxford, UK
- 2. Paediatrics, Microbiology, Medicine and Neurosurgery, The University of Alabama, Birmingham, USA
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