Structural Studies of NEMO and TRAF6: Implications in NF-κB Activation

Conference paper

DOI: 10.1007/978-1-4419-6612-4_9

Volume 691 of the book series Advances in Experimental Medicine and Biology (AEMB)
Cite this paper as:
Wu H., Lo YC., Yin Q. (2011) Structural Studies of NEMO and TRAF6: Implications in NF-κB Activation. In: Wallach D., Kovalenko A., Feldmann M. (eds) Advances in TNF Family Research. Advances in Experimental Medicine and Biology, vol 691. Springer, New York, NY

Abstract

NF-κB proteins are evolutionarily conserved master regulators of immune and inflammatory responses [2]. They play critical roles in a wide array of biological processes including innate and adaptive immunity, oncogenesis, and development. They are activated in response to ligation of many receptors including T-cell receptors, B-cell receptors, members of the tumor necrosis factor (TNF) receptor superfamily, and the Toll-like receptor/interleukin-1 receptor (TLR/IL-1R) superfamily.

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of BiochemistryWeill Cornell Medical CollegeNew YorkUSA