A Hybrid Multi-Distance Phase and Broadband Spatially Resolved Spectrometer and Algorithm for Resolving Absolute Concentrations of Chromophores in the Near-Infrared Light Spectrum

  • Ilias Tachtsidis
  • Lei Gao
  • Terence S. Leung
  • Matthias Kohl-Bareis
  • Chris E. Cooper
  • Clare E. Elwell
Conference paper

DOI: 10.1007/978-1-4419-1241-1_24

Volume 662 of the book series Advances in Experimental Medicine and Biology (AEMB)
Cite this paper as:
Tachtsidis I., Gao L., Leung T.S., Kohl-Bareis M., Cooper C.E., Elwell C.E. (2010) A Hybrid Multi-Distance Phase and Broadband Spatially Resolved Spectrometer and Algorithm for Resolving Absolute Concentrations of Chromophores in the Near-Infrared Light Spectrum. In: Takahashi E., Bruley D. (eds) Oxygen Transport to Tissue XXXI. Advances in Experimental Medicine and Biology, vol 662. Springer, Boston, MA

Abstract

For resolving absolute concentration of tissue chromophores in the human adult brain with near-infrared spectroscopy it is necessary to calculate the light scattering and absorption, at multiple wavelengths with some depth resolution. To achieve this we propose an instrumentation configuration that combines multi-distance frequency and broadband spectrometers to quantify chromophores in turbid media by using a hybrid spatially resolved algorithm. Preliminary results in solid phantoms as well as liquid dynamic homogeneous and inhomogeneous phantoms and in-vivo muscle measurements showed encouraging results.

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ilias Tachtsidis
    • 1
  • Lei Gao
    • 1
  • Terence S. Leung
    • 2
  • Matthias Kohl-Bareis
    • 3
  • Chris E. Cooper
    • 4
  • Clare E. Elwell
    • 1
  1. 1.Biomedical Optics Research Laboratory, Department of Medical Physics and BioengineeringUniversity College LondonLondonUK
  2. 2.Biomedical Optics Research Laboratory, Department of Medical Physics and BioengineeringUniversity College LondonLondonUK
  3. 3.University of Applied Sciences KoblenzRemagenGermany
  4. 4.Department of Biological SciencesCentre for Sports and Exercise Science, University of EssexColchesterUK