Chapter

Oxygen Transport to Tissue XXXI

Volume 662 of the series Advances in Experimental Medicine and Biology pp 169-175

Date:

A Hybrid Multi-Distance Phase and Broadband Spatially Resolved Spectrometer and Algorithm for Resolving Absolute Concentrations of Chromophores in the Near-Infrared Light Spectrum

  • Ilias TachtsidisAffiliated withBiomedical Optics Research Laboratory, Department of Medical Physics and Bioengineering, University College London Email author 
  • , Lei GaoAffiliated withBiomedical Optics Research Laboratory, Department of Medical Physics and Bioengineering, University College London
  • , Terence S. LeungAffiliated withBiomedical Optics Research Laboratory, Department of Medical Physics and Bioengineering, University College London
  • , Matthias Kohl-BareisAffiliated withUniversity of Applied Sciences Koblenz
  • , Chris E. CooperAffiliated withDepartment of Biological Sciences, Centre for Sports and Exercise Science, University of Essex
  • , Clare E. ElwellAffiliated withBiomedical Optics Research Laboratory, Department of Medical Physics and Bioengineering, University College London

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Abstract

For resolving absolute concentration of tissue chromophores in the human adult brain with near-infrared spectroscopy it is necessary to calculate the light scattering and absorption, at multiple wavelengths with some depth resolution. To achieve this we propose an instrumentation configuration that combines multi-distance frequency and broadband spectrometers to quantify chromophores in turbid media by using a hybrid spatially resolved algorithm. Preliminary results in solid phantoms as well as liquid dynamic homogeneous and inhomogeneous phantoms and in-vivo muscle measurements showed encouraging results.