Chapter

Structure and Function of the Neural Cell Adhesion Molecule NCAM

Volume 663 of the series Advances in Experimental Medicine and Biology pp 137-147

Date:

Use of PSA-NCAM in Repair of the Central Nervous System

  • Abderrahman El MaaroufAffiliated withDepartment of Cell Biology, Memorial Sloan-Kettering Cancer Center Email author 
  • , Urs RutishauserAffiliated withDepartment of Cell Biology, Memorial Sloan-Kettering Cancer Center

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Abstract

Polysialic acid (PSA) is a highly hydrated polymer whose presence at the cell surface can reduce cell interactions, and thereby increase tissue and cellular plasticity. Given its ability to create a permissive environment for cell migration and axonal growth, the potential of engineered overexpression of PSA to promote tissue repair has been explored in the adult CNS. Several promising results have been obtained that suggest that PSA engineering may become a valuable therapeutic tool.

Keywords

Polysialic acid Plasticity Brain lesion Regeneration Stem cells