Chapter

Osteoimmunology

Volume 658 of the series Advances in Experimental Medicine and Biology pp 111-116

Date:

Regulation of Osteoclast Apoptosis by Bcl-2 Family Protein Bim and Caspase-3

  • Sakae TanakaAffiliated withDepartment of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo
  • , Hidetoshi WakeyamaAffiliated withDepartment of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo
  • , Toru AkiyamaAffiliated withDepartment of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo
  • , Katsuhiko TakahashiAffiliated withDepartment of Biological Chemistry, School of Pharmaceutical Sciences, Showa University
  • , Hitoshi AmanoAffiliated withDepartment of Pharmacology, School of Dentistry, Showa University
  • , Keiichi I. NakayamaAffiliated withDepartment of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
  • , Kozo NakamuraAffiliated withDepartment of Orthopaedic Surgery, Faculty of Medicine

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Abstract

Apopotosis of osteoclasts is regulated by the Bcl-2 family protein Bim. Bim is degraded in the course of osteoclast apoptosis, which is regulated by Caspase-3. Osteoclasts generated from caspase-3 –/– mice exhibited a shorter life span and a higher bone-resorbing activity than those generated from normal littermates. These results suggest the important role of Caspase-3-Bim axis in regulating both apoptosis and activation of osteoclasts.

Keywords

Osteoclast Apoptosis Bim Caspase-3