Translation Attenuation Mechanism in Unfolded Protein Response
- Cite this paper as:
- Trusina A., Papa F., Tang C. (2008) Translation Attenuation Mechanism in Unfolded Protein Response. In: Skjeltorp A.T., Belushkin A.V. (eds) Evolution from Cellular to Social Scales. NATO Science for Peace and Security Series B: Physics and Biophysics. Springer, Dordrecht
Endoplasmic Reticulum is a cellular organelle where membrane and extracellular proteins are folded with the help of chaperons. Insulin is one example of such extracellular proteins. Unfolded Protein Response (UPR) is a cell response to an increased level of unfolded proteins in ER. In pancreatic β-cells failure in UPR leads to accumulation of unfolded insulin in Endoplasmic reticulum and eventual cell death. This is thought to be one of the causes of type two diabetes.
KeywordsUPR stress response translational attenuation unfolded protein response
Unable to display preview. Download preview PDF.