Translation Attenuation Mechanism in Unfolded Protein Response

  • Ala Trusina
  • Feroz Papa
  • Chao Tang
Conference paper

DOI: 10.1007/978-1-4020-8761-5_6

Part of the book series NATO Science for Peace and Security Series B: Physics and Biophysics (NAPSB)
Cite this paper as:
Trusina A., Papa F., Tang C. (2008) Translation Attenuation Mechanism in Unfolded Protein Response. In: Skjeltorp A.T., Belushkin A.V. (eds) Evolution from Cellular to Social Scales. NATO Science for Peace and Security Series B: Physics and Biophysics. Springer, Dordrecht

Abstract

Endoplasmic Reticulum is a cellular organelle where membrane and extracellular proteins are folded with the help of chaperons. Insulin is one example of such extracellular proteins. Unfolded Protein Response (UPR) is a cell response to an increased level of unfolded proteins in ER. In pancreatic β-cells failure in UPR leads to accumulation of unfolded insulin in Endoplasmic reticulum and eventual cell death. This is thought to be one of the causes of type two diabetes.

Keywords

UPR stress response translational attenuation unfolded protein response 

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Copyright information

© Springer Science + Business Media B.V 2008

Authors and Affiliations

  • Ala Trusina
    • 1
  • Feroz Papa
    • 1
  • Chao Tang
    • 1
  1. 1.QB3University of California at San FranciscoUSA