Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response

Volume 11 of the series Cancer Growth and Progression pp 169-191

Immunological aspects of Marek’s disease virus (MDV)-induced lymphoma progression

Immune Suppression and Modulation
  • Mark S. ParcellsAffiliated withO-404, Center of Excellence for Poultry Science, University of ArkansasUniversity of Delaware
  • , Shane C. BurgessAffiliated withDepartment of Basic Sciences, College of Veterinary Medicine, Mississippi State University

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Marek’s disease is a highly transmissible T-cell lymphoma of chickens caused by the only known acutely transforming alphaherpesvirus, Marek’s disease virus (MDV). Losses due to MDV-induced tumors (lymphomas, skin leukoses, etc.) have been minimized in poultry production since the early 1970s through the use of non-sterilizing vaccines. Initial lymphoma development in MDV-infected chickens is dependent on the challenge strain of MDV, the genetic susceptibility of the exposed chickens, the level of challenge and relative exposure to other adventitious agents. In this chapter, we examine the factors affecting the progression of MDV-induced, CD4+ T-lymphomas as a consequence of the immune insult incurred by the host during early lytic and latent phases of MDV infection, and as a consequence of the factors expressed by the transformed T-lymphoblasts. A special emphasis has been placed on the role of de-regulated host surface antigen expression on lymphoma progression. Several of these antigens (CD29/CD49e, CD30, CD44) are common to invasive and metastatic human lymphomas, suggesting common mechanisms of immune modulation in lymphoma progression.


Marek’s disease lymphoma progression herpesvirus oncology immunophenotype lymphomagenesis