Chapter

Programmed Cell Death in Cancer Progression and Therapy

Volume 615 of the series Advances in Experimental Medicine and Biology pp 25-45

The Mitochondrial Death Pathway

  • Anas ChalahAffiliated withDepartment of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center
  • , Roya Khosravi-FarAffiliated withDepartment of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center

Mitochondria have long been known to be critical for cell survival due to their role in energy metabolism. However, not until the mid-1990s did it become evident that mitochondria are also active participants in programmed cell death (PCD). This chapter focuses mainly on the role the mitochondria in mammalian cell death and cancer progression and therapy.

Keywords

apoptosis death receptors mitochondria bid membranes phospholipases cardiolipin