Chapter

Peroxiredoxin Systems

Volume 44 of the series Subcellular Biochemistry pp 115-141

The Peroxiredoxin Repair Proteins

  • Thomas J. JönssonAffiliated withCenter for Structural Biology, Department of Biochemistry, Wake Forest University School of Medicine
  • , W. Todd LowtherAffiliated withCenter for Structural Biology, Department of Biochemistry, Wake Forest University School of Medicine

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Abstract

Sulfiredoxin and sestrin are cysteine sulfinic acid reductases that selectively reduce or repair the hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. As such these enzymes play key roles in the modulation of peroxide-mediated cell signaling and cellular defense mechanisms. The unique structure of sulfiredoxin facilitates access to the peroxiredoxin active site and novel sulfur chemistry

Keywords

Cysteine sulfinic acid Retroreduction Sulfiredoxin Sestrin