Chapter

Oxygen Transport to Tissue XXX

Volume 645 of the series Advances in Experimental Medicine and Biology pp 315-320

Relationship Between Brain Tissue Haemodynamics, Oxygenation And Metabolism In The Healthy Human Adult Brain During Hyperoxia And Hypercapnea

  • Ilias TachtsidisAffiliated withDepartment of Medical Physics and Bioengineering Malet Place Engineering Building, University College
  • , Martin M. TisdallAffiliated withDepartment of Neuroanaesthesia and Neurocritical Care, The National Hospital for Neurology and Neurosurgery
  • , Terence S. LeungAffiliated withDepartment of Medical Physics and Bioengineering Malet Place Engineering Building, University College
  • , Caroline PritchardAffiliated withDepartment of Neuroanaesthesia and Neurocritical Care, The National Hospital for Neurology and Neurosurgery
  • , Christopher E. CooperAffiliated withDepartment of Biological Sciences, University of Essex
  • , Martin SmithAffiliated withDepartment of Neuroanaesthesia and Neurocritical Care, The National Hospital for Neurology and Neurosurgery
  • , Clare E. ElwellAffiliated withDepartment of Medical Physics and Bioengineering Malet Place Engineering Building, University College

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Abstract

This study investigates the relationship between changes in brain tissue haemodynamics, oxygenation and oxidised cytochrome-c-oxidase ([oxCCO]) in the adult brain during hyperoxia and hypercapnea. 10 healthy volunteers were studied. We measured the mean blood flow velocity of the right middle cerebral artery (Vmca) with transcranial Doppler (TCD) and changes in concentrations of total haemoglobin ([HbT]=[HbO2]+[HHb]), haemoglobin difference ([Hbdiff]=[HbO2]-[HHb]) and [oxCCO] with broadband near-infrared spectroscopy (NIRS). We also measured the absolute tissue oxygenation index (TOI) using NIR spatially resolved spectroscopy. During hyperoxia there was an increase in TOI (2.33±0.29%), [Hbdiff] (4.57±1.27⎧M) and in the oxidation of [oxCCO] (0.09±0.12⎧M); but a reduction in Vmca (5.85±4.85%) and HbT (1.29±0.91⎧M). During hyperoxia there was a positive correlation between [oxCCO] and TOI and [Hbdiff] (r=0.83 and r=0.95) and a negative association between [oxCCO] and Vmca and [HbT] (r=-0.74 and r=-0.87). During hypercapnea there was an increase in TOI (2.76±2.16%), [Hbdiff] (7.36±2.64), [HbT] (2.61±2.7⎧M), Vmca (14.92±17.5%) and in the oxidation of [oxCCO] (0.25±0.17⎧M). Correlation analysis shows that there was association between [oxCCO] and TOI, [Hbdiff] and [HbT] (r=0.83, r=0.93 and r=0.82) but not with Vmca (r=0.33). We conclude that an increase in [oxCCO] was seen during both challenges and it was highly associated with brain tissue oxygenation.