Coagulation in Cancer

Volume 148 of the series Cancer Treatment and Research pp 137-156


Disseminated Intravascular Coagulation (DIC) in Cancer

  • Hussain I. SabaAffiliated withHemophilia-Hemostasis-Thrombosis Center, Department of Internal Medicine, University of South Florida College of Medicine Email author 
  • , Genevieve A. MorelliAffiliated withDepartment of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute
  • , Rashid I. SabaAffiliated withSection of Hematology/ Oncology, Medical Service, James A. Haley Veterans Hospital, #111R

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Venous thromboembolism (VTE) and disseminated intravascular coagulation (DIC) are important complications of cancer. The relationship was recognized as early as 1800 when Professor Armand Trousseau noted that patients with idiopathic VTE frequently harbor an occult cancer [1, 2]. Prandoni reported a 7.6% incidence of cancer in 145 patients following idiopathic VTE [3]. In 2000, Schulman reported that 13% of patients in his study developed cancer after their initial diagnosis of primary VTE [4]. We reported that 26.2% of veteran patients were diagnosed to have cancer within 6 months after initial VTE as compared to 11.5% of the control group [5]. These studies emphasize that there is an intimate relation between VTE and cancer.