Chapter

Eukaryotic Membranes and Cytoskeleton

Volume 607 of the series Advances in Experimental Medicine and Biology pp 61-72

Evolution of the Endoplasmic Reticulum and the Golgi Complex

  • Alexander A. MironovAffiliated withDepartment of Cell Biology and Oncology, Mario Negri Sud Institute Email author 
  • , Victor V. BaninAffiliated withResearch Center, Russian State Medical University
  • , Irina S. SesorovaAffiliated withDepartment of Biology, Shuja State Pedagogical University
  • , Viacheslav V. DolgikhAffiliated withLaboratory of Microbiological Control All-Russian Institute for Plant Protection, Russian Academy of Agricultural Sciences
  • , Alberto LuiniAffiliated withDepartment of Cell Biology and Oncology, Mario Negri Sud Institute
  • , Galina V. BeznoussenkoAffiliated withDepartment of Cell Biology and Oncology, Mario Negri Sud Institute

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Abstract

By analyzing the morpho-physiological features of the Golgi complex, its relationship with the endoplasmic reticulum in different species, and the molecular machineries involved in intracellular transport, we conclude that; (1) all eukaryotic cells have either Golgi complexes or remnants thereof; (2) all eukaryotic cells have a large minimal set of proteins that are involved in intracellular transport; and (3) several indispensable molecular machines are always present in secreting eukaryotic cells. Using this information, our data about mechanisms of intra-Golgi transport and phylogenetic analysis of several molecular machines, we propose a model for the evolution of the Golgi complex and the endoplasmic reticulum.