Targeted Therapies in Cancer

Volume 610 of the series Advances in Experimental Medicine and Biology pp 112-127

Linking Inflammation Reactions to Cancer: Novel Targets for Therapeutic Strategies

  • Alberto MantovaniAffiliated withIstituto Clinico Humanitas IRCCSCentro di Eccellenza per l'Innovazione Diagnostica e Terapeutica, Institute of Pathology, University of Milan
  • , Federica MarchesiAffiliated withIstituto Clinico Humanitas IRCCS
  • , Chiara PortaAffiliated withIstituto Clinico Humanitas IRCCS
  • , Paola AllavenaAffiliated withIstituto Clinico Humanitas IRCCS
  • , Antonio SicaAffiliated withIstituto Clinico Humanitas IRCCS

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An inflammatory component is present in the microenvironment of most neoplastic tissues, including those not causally related to an obvious inflammatory process. Epidemiological studies have revealed that chronic inflammation predisposes to different forms of cancer and that usage of non-steroidal, anti-inflammatory agents is associated with protection against various tumors. The infiltration of white blood cells, the presence of polypeptide messengers of inflammation (cytokines and chemokines), the occurrence of tissue remodeling and angiogenesis, represent hallmarks of cancer-associated inflammation.