Interaction Between Neurons and Glia in Aging and Disease

pp 111-120

Neuron-Glia Interaction in Homeostasis of the Neurotransmitters Glutamate and GABA

  • Arne SchousboeAffiliated withDept. Pharmacol, Danish Univ. Pharm. Sci.
  • , Helle S. WaagepetersenAffiliated withDept. Pharmacol, Danish Univ. Pharm. Sci.

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The functional activity in the brain is primarily composed of interplay between excitation and inhibition. In any given region the output is based upon a complex processing of incoming signals that require both excitatory and inhibitory units. Moreover, these units must be regulated and balanced such that an integrated and finely tuned response is generated. In each of these units or synapses, the activity depends on biosynthesis, release, receptor interaction, and inactivation of the neurotransmitters; thus, it is easily understood that each of these processes needs to be highly regulated and controlled.