Role of Host Genetic Susceptibility in the Pathogenesis of Gastric Cancer

* Final gross prices may vary according to local VAT.

Get Access
This is an excerpt from the content

Introduction

At the turn of the twentieth century, gastric cancer was the leading cause of cancer-related death in many Western countries but the incidence has steadily decreased over the past 70 years. Globally, gastric cancer is the second most common cause of cancer-related death and, as a result of population aging and growth, the predicted incidence for 2010 is 1.1 million with the majority of this health burden borne by economically lesser-developed countries.1 In this chapter, we hope to shed some light on the role of host genetic susceptibility in the pathogenesis of gastric cancer. In particular, we attempt to demonstrate how interactions among an infectious agent, host genetic makeup, and environmental factors could influence the pathogenesis of this cancer. The infectious agent in question is Helicobacter pylori, the world's most common chronic bacterial infection and the malignancy is gastric cancer, second only to lung cancer in its global incidence and impact.