Chapter

Neural Crest Induction and Differentiation

Volume 589 of the series Advances in Experimental Medicine and Biology pp 213-234

Molecular Bases of Human Neurocristopathies

  • Heather C. EtcheversAffiliated withINSERM U393, Hôpital Necker — Enfants Malades Email author 
  • , Jeanne AmielAffiliated withDépartement de Génétique Médicale et Unité INSERM U-393, Hôpital Necker-Enfants Malades
  • , Stanislas LyonnetAffiliated withDépartement de Génétique Médicale et Unité INSERM U-393, Hôpital Necker-Enfants Malades

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Abstract

Neural crest cells (NCC) form in the human embryo during the third to fifth weeks of pregnancy, within the neural folds that delineate the neural plate from the ectoderm. During the fusion of the neural folds, which ultimately yields a tube that will become the central nervous system (CNS), NCC detach and become mesenchymal. They migrate throughout the body, integrating nearly every organ.