Molecular Bases of Human Neurocristopathies

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Neural crest cells (NCC) form in the human embryo during the third to fifth weeks of pregnancy, within the neural folds that delineate the neural plate from the ectoderm. During the fusion of the neural folds, which ultimately yields a tube that will become the central nervous system (CNS), NCC detach and become mesenchymal. They migrate throughout the body, integrating nearly every organ.