Chapter

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease

Volume 595 of the series ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY pp 127-148

MODULATION OF TRANSCRIPTION FACTORS BY CURCUMIN

  • Shishir Shishodia
  • , Tulika Singh
  • , Madan M. Chaturvedi

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Abstract

Curcumin is the active ingredient of turmeric that has been consumed as a dietary spice for ages. Turmeric is widely used in traditional Indian medicine to cure biliary disorders, anorexia, cough, diabetic wounds, hepatic disorders, rheumatism, and sinusitis. Extensive investigation over the last five decades has indicated that curcumin reduces blood cholesterol, prevents low-density lipoprotein oxidation, inhibits platelet aggregation, suppresses thrombosis and myocardial infarction, suppresses symptoms associated with type II diabetes, rheumatoid arthritis, multiple sclerosis, and Alzheimer’s disease, inhibits HIV replication, enhances wound healing, protects from liver injury, increases bile secretion, protects from cataract formation, and protects from pulmonary toxicity and fibrosis. Evidence indicates that the divergent effects of curcumin are dependent on its pleiotropic molecular effects.