Chapter

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease

Volume 595 of the series ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY pp 453-470

PHARMACOKINETICS AND PHARMACODYNAMICS OF CURCUMIN

  • Ricky A. Sharma
  • , William P. Steward
  • , Andreas J. Gescher

Abstract

Curcuma spp. contain turmerin, essential oils, and curcuminoids, including curcumin. Curcumin [1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6- heptadiene-3,5-dione] is regarded as the most biologically active constituent of the spice turmeric and it comprises 2–8% of most turmeric preparations. Preclinical data from animal models and phase I clinical studies performed with human volunteers and patients with cancer have demonstrated low systemic bioavailability following oral dosing.