Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks

Volume 594 of the series Advances in Experimental Medicine and Biology pp 1-13

Protein Misassembly

Macromolecular Crowding and Molecular Chaperones
  • R. John EllisAffiliated withDepartment of Biological Sciences, University of Warwick

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The generic tendency of proteins to misassemble into nonfunctional, and sometimes cytotoxic, structures poses a universal problem for all types of cell. This problem is exacerbated by the high total concentration of macromolecules found within most in-tracellular compartments but it is solved by the actions of molecular chaperones. This review discusses some of the basic evidence and key concepts relating to this conclusion.