Biglycan Is a Positive Modulator of BMP-2 Induced Osteoblast Differentiation

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Abstract

Development of the vertebrate skeleton is a complex process involving genes that control a series of cellular events such as proliferation, migration, mesenchymal condensations and eventually differentiation into osteoblasts and chondrocytes1. For osteoblast differentiation, an intricate and highly regulated interplay of growth factors, receptors/co-receptors, specific extracellular milieu and transcription factors is required2. Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF- ) superfamily, are multifunctional growth factors critically involved in osteoblast differentiation. The BMP functions are exerted through their interaction with specific cell surface receptors, BMP type I and II receptors, leading to the regulation of specific BMP target genes. The signaling is regulated at numerous steps at extracellular, cell surface and intracellular levels3, 4.