Assessment of Chimerism in the Setting of Allogeneic Hematopoietic Cell Transplantation

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Abstract

Hematopoietic cell transplantation (HCT) has become a well-established treatment option for a variety of malignant and nonmalignant diseases. Molecular analysis of chimerism is used to monitor the levels of donor and recipient cells in patients after HCT. The clinical utility and interpretation of chimerism analysis depend on the type of bone marrow transplant used and the underlying disease. After transplantation, chimerism analysis is used to confirm engraftment of donor hematopoiesis and identify and quantify the percentage of recipient cells to guide patient management aimed at helping to prevent graft failure or relapse.