When, How, and Where can Oral Cholera Vaccines be Used to Interrupt Cholera Outbreaks?
- John ClemensAffiliated withICCDR,BUCLA School of Public Health Email author
- , Jan HolmgrenAffiliated withUniversity of Gothenburg
Cholera continues to be a major global health problem, at times causing major and prolonged outbreaks in both endemic and nonendemic settings in developing countries. While improved water quality, sanitation, and hygiene (WASH) will provide the ultimate solution to prevention of this disease burden, this is a far-off goal for most developing countries. Oral cholera vaccines (OCVs) have been demonstrated to be effective in the control of cholera outbreaks, and constitute useful tools to be used in conjunction with efforts to improve WASH. Two killed OCVs are prequalified by WHO for purchase by UN agencies for international use. Recently, WHO has launched a global stockpile of killed OCVs for use to control outbreaks. Rational deployment of OCV from this stockpile will require consideration of costs, feasibility, disease epidemiology , and the protective characteristics of the vaccine deployed, as well as effective and rapid coordination of processes and logistics used to make decisions on deployment and delivery of the vaccine to the population in need. Despite not having data on all the questions of relevance as to how to use OCVs to control cholera outbreaks in different settings, there is clearly more than enough evidence to initiate their use, as answers to remaining questions and refinement of policies will mainly come with experience.
- When, How, and Where can Oral Cholera Vaccines be Used to Interrupt Cholera Outbreaks?
- Book Title
- Cholera Outbreaks
- pp 231-258
- Print ISBN
- Online ISBN
- Series Title
- Current Topics in Microbiology and Immunology
- Series Volume
- Series ISSN
- Springer Berlin Heidelberg
- Copyright Holder
- Springer-Verlag Berlin Heidelberg
- Additional Links
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- Editor Affiliations
- 12. Translational Health Science and Technology Institute
- 13. National Institute of Infectious Diseases
- Author Affiliations
- 14. ICCDR,B, Dhaka, Bangladesh
- 15. UCLA School of Public Health, Los Angeles, USA
- 16. University of Gothenburg, Gothenburg, Sweden
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