Chapter

Notch Regulation of the Immune System

Volume 360 of the series Current Topics in Microbiology and Immunology pp 75-97

Date:

Notch Signaling During Human T cell Development

  • Tom TaghonAffiliated withDepartment of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent University Email author 
  • , Els WaegemansAffiliated withDepartment of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent University
  • , Inge Van de WalleAffiliated withDepartment of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent University

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Abstract

Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species. Here, we review our current understanding of how Notch signaling is activated and used during human T cell development. First, we set the stage by describing the developmental steps that make up human T cell development before describing the expression profiles of Notch receptors, ligands, and target genes during this process. To delineate stage-specific roles for Notch signaling during human T cell development, we subsequently try to interpret the functional Notch studies that have been performed in light of these expression profiles and compare this to its suggested role in the mouse.