Chapter

Negative Co-Receptors and Ligands

Volume 350 of the series Current Topics in Microbiology and Immunology pp 89-104

Date:

Immunoregulatory Roles for Fc Receptor-Like Molecules

  • Götz R. A. EhrhardtAffiliated withDepartment of Pathology and Laboratory Medicine, Emory University School of MedicineEmory Vaccine Center, Emory University School of Medicine
  • , Max D. CooperAffiliated withDepartment of Pathology and Laboratory Medicine, Emory University School of MedicineEmory Vaccine Center, Emory University School of MedicineGeorgia Research AllianceEmory Center for AIDS Research, Rollins School of Public Health, Emory University Email author 

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Abstract

Fc receptor-like (FCRL) molecules comprise a family of imunoregulatory transmembrane proteins that are preferentially, but not exclusively expressed on B lineage cells. A strong regulatory potential on B cell activation has been characterized for the different FCRL proteins, but their biological roles are just beginning to be elucidated. We review recent advances in the understanding of FCRL1-6 expression and function, and indicate their potential roles in the pathogenesis of immunodeficiencies, lymphoid malignancies and autoimmune diseases.