Negative Co-Receptors and Ligands

Volume 350 of the series Current Topics in Microbiology and Immunology pp 105-125


FcγRs in Health and Disease

  • Falk NimmerjahnAffiliated withChair of Genetics, University of Erlangen-Nuremberg Email author 
  • , Jeffrey V. RavetchAffiliated withLaboratory of Molecular Genetics and Immunology, The Rockefeller University

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Genetic defects affecting the humoral immune response and especially the production of antibodies of the immunoglobulin G (IgG) isotype result in a heightened susceptibility to infections. Studies over the last years have demonstrated the crucial role of Fc-receptors for IgG (FcγRs) widely expressed on innate immune effector cells in mediating the protective function of IgG. During the last years, additional ligands interacting with FcγRs as well as additional receptors binding to IgG glycosylation variants have been identified. In this review, we discuss how the interaction of these different ligands with classical and novel Fcγ-receptors influences the immune response and which strategies microorganisms have developed to prevent them.