Chapter

Small-Molecule Inhibitors of Protein-Protein Interactions

Volume 348 of the series Current Topics in Microbiology and Immunology pp 89-113

Date:

Design of Small-Molecule Smac Mimetics as IAP Antagonists

  • Shaomeng WangAffiliated withComprehensive Cancer Center, University of MichiganDepartment of Internal Medicine, University of MichiganDepartment of Pharmacology, University of MichiganDepartment of Medicinal Chemistry, University of Michigan Email author 

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Abstract

Smac/DIABLO, discovered in 2000 as a protein released from mitochondria into the cytosol in response to apoptotic stimuli, functions as an endogenous antagonist of X-linked inhibitor of apoptosis protein (XIAP) and several other IAP proteins through direct binding. The interaction between Smac and IAPs involves the AVPI tetrapeptide binding motif on the N-terminus of Smac and a well-defined groove on the surface of these IAP proteins, providing an ideal site for the design of small-molecule Smac mimetics. Potent and cell-permeable small-molecule Smac mimetics have provided powerful pharmacological tools for study of the regulation of apoptosis by IAP proteins, and several such compounds are now in early clinical trials as new anticancer agents.