Chapter

Neurogenesis and Neural Plasticity

Volume 15 of the series Current Topics in Behavioral Neurosciences pp 189-210

Date:

All About Running: Synaptic Plasticity, Growth Factors and Adult Hippocampal Neurogenesis

  • Carmen VivarAffiliated withNeuroplasticity and Behavior Unit, Laboratory of Neurosciences, NIA/NIH Biomedical Research Center
  • , Michelle C. PotterAffiliated withNeuroplasticity and Behavior Unit, Laboratory of Neurosciences, NIA/NIH Biomedical Research Center
  • , Henriette van PraagAffiliated withNeuroplasticity and Behavior Unit, Laboratory of Neurosciences, NIA/NIH Biomedical Research Center Email author 

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Abstract

Accumulating evidence from animal and human research shows exercise benefits learning and memory, which may reduce the risk of neurodegenerative diseases, and could delay age-related cognitive decline. Exercise-induced improvements in learning and memory are correlated with enhanced adult hippocampal neurogenesis and increased activity-dependent synaptic plasticity. In this present chapter we will highlight the effects of physical activity on cognition in rodents, as well as on dentate gyrus (DG) neurogenesis, synaptic plasticity, spine density, neurotransmission and growth factors, in particular brain-derived nerve growth factor (BDNF).

Keywords

Adult neurogenesis Dentate gyrus Running Learning and memory Neurotrophic factors Synaptic plasticity Endurance factors