Chapter

Bioactive Heterocycles VII

Volume 16 of the series Topics in Heterocyclic Chemistry pp 153-231

Date:

Bioactive Phenothiazines and Benzo[a]phenothiazines: Spectroscopic Studies, and Biological and Biomedical Properties and Applications

  • J. J. AaronAffiliated withITODYS, Université Paris 7 – Denis-Diderot, Associé au CNRS UMR 70-86Laboratoire des Géomatériaux et Géologie de l'Ingénieur (G2I), Université Paris-Est Marne la Vallée Email author 
  • , M. D. Gaye SeyeAffiliated withDépartement de Chimie, Faculté des Sciences et Techniques, Université Cheikh Anta Diop
  • , S. TrajkovskaAffiliated withDepartment of Medical and Experimental Biochemistry, Medical Faculty, University Sv Kiril i Metodij
  • , N. MotohashiAffiliated withDepartment of Medicinal Chemistry, Meiji Pharmaceutical University

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Abstract

Recent progress in spectroscopic, photophysical, photochemical and analytical studies, as well as in the biological and biomedical properties of bioactive phenothiazines and benzophenothiazines, is reviewed. Their electronic absorption and luminescence properties, and their complexation and interactions in organized media are discussed. Various applications, including analytical studies, relative to phenothiazines and benzophenothiazines are described. Among the important biological and biomedical properties of these compounds, their neurological effects, their antibacterial, antifungal, antiviral, antiparasitic and antitumour activities, and their cytotoxicity are particularly reviewed.

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Benzophenothiazines Biological and biomedical properties Phenothiazines Photophysical, photochemical and analytical studies Spectroscopic properties