Chapter

Emerging Organic Contaminants in Sludges

Volume 24 of the series The Handbook of Environmental Chemistry pp 165-213

Date:

Biodegradation of Pharmaceuticals by Fungi and Metabolites Identification

  • C. Cruz-MoratóAffiliated withDepartament d’Enginyeria Química, Universitat Autònoma de Barcelona (UAB)
  • , C. E. Rodríguez-RodríguezAffiliated withUnitat Asociada de Biocatàlisi Aplicada IQAC-CSIC, Escola d’Enginyeria, Universitat Autònoma de BarcelonaCentro de Investigación en Contaminación Ambiental (CICA), Universidad de Costa Rica
  • , E. Marco-UrreaAffiliated withDepartament d’Enginyeria Química, Universitat Autònoma de Barcelona (UAB)
  • , M. SarràAffiliated withDepartament d’Enginyeria Química, Universitat Autònoma de Barcelona (UAB)
  • , G. CaminalAffiliated withGrupo de biocatalisis Aplicada y biodegradación, IQAC-CSIC
  • , T. VicentAffiliated withDepartament d’Enginyeria Química, Universitat Autònoma de Barcelona (UAB)
  • , A. JelićAffiliated withDepartment of Environmental Chemistry, IDAEA, CSIC
  • , M. J. García-GalánAffiliated withDepartment of Environmental Chemistry, IDAEA, CSIC
  • , S. PérezAffiliated withDepartment of Environmental Chemistry, IDAEA, CSIC
    • , M. S. Díaz-CruzAffiliated withDepartment of Environmental Chemistry, IDAEA, CSIC
    • , M. PetrovićAffiliated withICREA Institució Catalana de Recerca i Estudis Avançats, Passeig Lluís CompanysCatalan Institute for Water Research (ICRA), Parc Científic i Tecnològic de la Universitat de Girona Email author 
    • , D. BarcelóAffiliated withDepartment of Environmental Chemistry, IDAEA, CSICCatalan Institute for Water Research (ICRA), Parc Científic i Tecnològic de la Universitat de Girona

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Abstract

Pharmaceutical compounds comprise a widely employed group of therapeutic agents now considered as emerging micropollutants. This chapter summarizes the state of the art in the degradation of pharmaceuticals by fungi in liquid matrices (with emphasis on white-rot fungi), including the use of both whole cells and fungal enzymes. The identification of the metabolites produced as well as the proposed degradation pathways available for some drugs are discussed. The information is organized according to the activity of the pharmaceutical compounds, grouped in: anti-inflammatory/analgesic drugs, psychiatric drugs, lipid regulators, antibiotics and other antimicrobial agents, β-blockers, estrogens, and iodinated contrast media. Considering the interest in potential application of fungal treatments in future real scale bioremediation of effluents, the ecotoxicology of the process is included when available.

Graphical Abstract

https://static-content.springer.com/image/chp%3A10.1007%2F698_2012_158/MediaObjects/270629_1_En_158_Figa_HTML.gif

Keywords

Degradation Pharmaceuticals Toxicity Transformation products White-rot fungi