Chapter

Pathobiology of Pulmonary Disorders

Volume 955 of the series Advances in Experimental Medicine and Biology pp 47-50

Date:

Whooping Cough in Adults: A Series of Severe Cases

  • K. ZycinskaAffiliated withDepartment of Family Medicine with Internal and Metabolic Diseases Ward, Warsaw Medical University Email author 
  • , M. CieplakAffiliated withDepartment of Family Medicine with Internal and Metabolic Diseases Ward, Warsaw Medical University
  • , M. ChmielewskaAffiliated withDepartment of Family Medicine with Internal and Metabolic Diseases Ward, Warsaw Medical University
  • , A. Nitsch-OsuchAffiliated withDepartment of Family Medicine with Internal and Metabolic Diseases Ward, Warsaw Medical University
  • , A. KlaczkowAffiliated withDepartment of Family Medicine with Internal and Metabolic Diseases Ward, Warsaw Medical University
  • , M. Hadzik-BlaszczykAffiliated withDepartment of Family Medicine with Internal and Metabolic Diseases Ward, Warsaw Medical University
  • , Z. KurAffiliated withDepartment of Family Medicine with Internal and Metabolic Diseases Ward, Warsaw Medical University
  • , K. A. WardynAffiliated withDepartment of Family Medicine with Internal and Metabolic Diseases Ward, Warsaw Medical University

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Abstract

Bordetella pertussis is a gram-negative aerobic coccobacillus causing contagious respiratory tract disease called whooping cough. The virulence factors consist of pertussis toxin, filamentous hemagglutinin, fimbriae, lipooligosaccharide, and adenylate cyclase toxin. The disease causes a worldwide threat to public health despite a high vaccination coverage. The course of whooping cough in adults is frequently atypical, causing difficulty in diagnosis. In this report we present five patients hospitalized with Bordetella pertussis infection manifesting atypical and severe symptoms. The diagnosis was based on serological tests: serum concentration of specific antibodies against pertussis toxin and sputum cultures. We observed a wide spectrum of symptoms, from benign (sinus pain – 80 %, headaches – 20 %), through moderate (hemoptysis – 40 %; chest pain 60 %) to severe symptoms (cardiac arrhythmia – 40 %; syncope – 60 %). Bordetella pertussis infection can cause life-threatening complications and exacerbation of concomitant chronic diseases. Most vaccination programs cover only the first few months of life. Booster doses should be considered in adults, especially those immunocompromised or with pulmonary complications, but also in healthcare workers who are exposed to the contagion and also may spread the infection.

Keywords

Bordetella pertussis Cardiac arrhythmia Chronic cough Syncope Vaccination booster Whooping cough