Chapter

Chemosensory Systems in Mammals, Fishes, and Insects

Volume 47 of the series Results and Problems in Cell Differentiation pp 25-36

Date:

Odorant Receptor Gene Choice and Axonal Projection in the Mouse Olfactory System

  • T. ImaiAffiliated withDepartment of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo
  • , H. SakanoAffiliated withDepartment of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo

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Abstract

In the mouse olfactory system, each olfactory sensory neuron (OSN) expresses a single type of odorant receptor (OR) out of approximately 1,000 in a monoallelic manner. Furthermore, OSNs expressing the same OR converge their axons to a specific set of glomeruli on the olfactory bulb. These two basic principles are fundamental to the peripheral olfactory system, and are regulated by the expressed OR protein itself. Singular OR gene choice is ensured by the combination of stochastic enhancer–promoter interaction and negative-feedback regulation by OR proteins. In the axonal projection, OR-derived cyclic AMP signals and neuronal activity determine the expression levels of axon guidance/sorting molecules, and thereby direct glomerular positioning and axon sorting.