Orphan G Protein-Coupled Receptors and Novel Neuropeptides

Volume 46 of the series Results and Problems in Cell Differentiation pp 181-199


Biological Function of Prokineticins

  • Q.-Y. ZhouAffiliated withDepartment of Pharmacology, University of California Email author 
  • , R. MeidanAffiliated withDepartment of Animal Sciences, The Hebrew University of Jerusalem

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Secreted peptides have been implicated in diverse physiological functions. Prokineticins are a pair of regulatory peptides that signal through two highly homologous G protein-coupled receptors. Prokineticins possess a unique structural motif of five disulfide bonds and conserved N-terminal stretches. Diverse biological functions, ranging from development to adult physiology, have been attributed to prokineticins. Herein we provide an overview of current knowledge of this interesting pair of regulatory peptides.

Angiogenesis Basic helix-loop-helix transcriptional factors Circadian rhythm G protein-coupled receptor Neurogenesis Neuropeptides Prokineticin